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A Study of Revumenib in Combination With Chemotherapy for Patients Diagnosed With Relapsed or Refractory Leukemia

Exploring new treatment options for relapsed or resistant leukemia.

Recruiting
1-6 years
All
Phase 2

This study is testing a new treatment for leukemia, a type of cancer that affects white blood cells. It looks at how safe and effective a medicine called revumenib is when used with chemotherapy, which is a type of cancer treatment. This study is for young children whose leukemia has come back or hasn't responded to treatment and involves a specific change in their genes, called KMT2A rearrangement.

Key Points:

  • This study involves several cycles of taking the medicine revumenib and chemotherapy, which can be given through the mouth or a tube.
  • Participants will need to visit the hospital regularly for tests, including blood samples and scans, to check how the treatment is working and monitor for side effects.
  • Participants must be under 6 years old, have a specific type of leukemia, and not have other health conditions like Down syndrome or certain infections.

It's important to discuss with doctors about the potential benefits and risks of participating, such as possible side effects and the commitment required for the study visits and treatments.

Study details
    Recurrent Acute Leukemia of Ambiguous Lineage
    Recurrent Acute Lymphoblastic Leukemia
    Recurrent Acute Myeloid Leukemia Due to Lineage Switch From Acute Leukemia of Ambiguous Lineage
    Recurrent Acute Myeloid Leukemia Due to Lineage Switch From B Acute Lymphoblastic Leukemia
    KMT2A-Rearranged
    Recurrent Acute Myeloid Leukemia Due to Lineage Switch From Mixed Phenotype Acute Leukemia
    Recurrent Mixed Phenotype Acute Leukemia
    Refractory Acute Leukemia of Ambiguous Lineage
    Refractory Acute Lymphoblastic Leukemia
    Refractory Acute Myeloid Leukemia Due to Lineage Switch From Acute Leukemia of Ambiguous Lineage
    Refractory Acute Myeloid Leukemia Due to Lineage Switch From B Acute Lymphoblastic Leukemia
    KMT2A-Rearranged
    Refractory Acute Myeloid Leukemia Due to Lineage Switch From Mixed Phenotype Acute Leukemia
    Refractory Mixed Phenotype Acute Leukemia

NCT05761171

Children's Oncology Group

15 February 2025

Step 1 Get in touch with the nearest study center
What happens next?
  • You can expect the study team to contact you via email or phone in the next few days.
  • Sign up as volunteer  to help accelerate the development of new treatments and to get notified about similar trials.

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FAQs

Learn more about clinical trials

What is a clinical trial?

A clinical trial is a study designed to test specific interventions or treatments' effectiveness and safety, paving the way for new, innovative healthcare solutions.

Why should I take part in a clinical trial?

Participating in a clinical trial provides early access to potentially effective treatments and directly contributes to the healthcare advancements that benefit us all.

How long does a clinical trial take place?

The duration of clinical trials varies. Some trials last weeks, some years, depending on the phase and intention of the trial.

Do I get compensated for taking part in clinical trials?

Compensation varies per trial. Some offer payment or reimbursement for time and travel, while others may not.

How safe are clinical trials?

Clinical trials follow strict ethical guidelines and protocols to safeguard participants' health. They are closely monitored and safety reviewed regularly.
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