EMANATE Study is researching setmelanotide, a medicine for obesity, in people with certain gene changes in the MC4R pathway. These genes include POMC, PCSK1, LEPR, SRC1, and SH2B1. The study is randomized (participants are chosen by chance), double-blind (neither doctors nor participants know who gets the actual medicine), and placebo-controlled (some get the real medicine, others get a fake one for comparison). Participants need to be aged 6-65, have obesity, and specific gene changes. Obesity means having a Body Mass Index (BMI) of 30 or more for adults, or in the top 5% for kids. Hyperphagia means excessive hunger. To join, people must not have lost a lot of weight recently, had weight surgery, or certain health issues. Women cannot be pregnant or breastfeeding.
- Length: Study lasts several months; details provided upon enrollment.
- Visits: Multiple doctor visits needed during the study.
- Risks: Some side effects or health risks may occur.