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Testing the Use of Steroids and Tyrosine Kinase Inhibitors With Blinatumomab or Chemotherapy for Newly Diagnosed BCR-ABL-Positive Acute Lymphoblastic Leukemia in Adults

Trying new treatments for adults with specific leukemia types.

Recruiting
18-75 years
All
Phase 3
  • Simplified description (AI rewritten)
  • Technical description (Original)

This study is for adults with a type of blood cancer called BCR-ABL-Positive Acute Lymphoblastic Leukemia (ALL). It tests if adding a new medicine called blinatumomab to the usual treatment of chemotherapy, steroids, and a tyrosine kinase inhibitor (TKI) helps patients live longer. Blinatumomab is a Bi-specific T-Cell Engager (BiTE) that helps the body fight cancer cells. The study will compare this new combination to the standard treatment to see which works better. A tyrosine kinase inhibitor (TKI) is a medicine that stops cancer cells from growing.

  • Study Length: The study involves multiple visits over several years, with follow-ups every 3 months for 2 years, then less often until year 10.
  • Eligibility: Participants must be 18-75 years old, have newly diagnosed BCR-ABL-positive ALL, and meet specific health criteria.
  • Compensation: Not specified, but participants may receive study-related medical care at no cost.

This study may involve risks like side effects from the medicines used. Participants will be closely monitored by doctors. This study might help find better ways to treat this type of leukemia.

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Study details
    B Acute Lymphoblastic Leukemia With t(9;22)(q34.1;q11.2); BCR-ABL1

NCT04530565

National Cancer Institute (NCI)

8 March 2025

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