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The Safety and Efficacy of Alpha-1 Antitrypsin (AAT) for the Prevention of Graft-versus-host Disease (GVHD) in Patients Receiving Hematopoietic Cell Transplant

Testing AAT for preventing GVHD in transplant patients.

Recruiting
12 years and older
All
Phase 2/3

This study explores the safety and effectiveness of a protein called **Alpha-1 Antitrypsin (AAT)** in stopping a condition called Graft-Versus-Host Disease (GVHD). GVHD can occur after a **Hematopoietic Cell Transplant (HCT)**, a procedure where healthy blood-forming cells are given to someone with blood cancer. The study is double-blind, which means neither the doctors nor the participants know who gets AAT or a placebo (a fake treatment). This helps make the results fair.

To join the study, you must be 12 or older (18+ in Germany) and getting a transplant for certain blood cancers like leukemia. You cannot join if you’ve had a transplant before or if certain treatments are part of your plan.

  • The study will be conducted in multiple centers and is divided into two phases.
  • Participants will be randomly assigned to receive either AAT or a placebo.
  • It is important to discuss potential risks and benefits with your doctor.
Study details
    Acute-graft-versus-host Disease

NCT03805789

CSL Behring

15 March 2025

Step 1 Get in touch with the nearest study center
What happens next?
  • You can expect the study team to contact you via email or phone in the next few days.
  • Sign up as volunteer  to help accelerate the development of new treatments and to get notified about similar trials.

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Learn more about clinical trials

What is a clinical trial?

A clinical trial is a study designed to test specific interventions or treatments' effectiveness and safety, paving the way for new, innovative healthcare solutions.

Why should I take part in a clinical trial?

Participating in a clinical trial provides early access to potentially effective treatments and directly contributes to the healthcare advancements that benefit us all.

How long does a clinical trial take place?

The duration of clinical trials varies. Some trials last weeks, some years, depending on the phase and intention of the trial.

Do I get compensated for taking part in clinical trials?

Compensation varies per trial. Some offer payment or reimbursement for time and travel, while others may not.

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Clinical trials follow strict ethical guidelines and protocols to safeguard participants' health. They are closely monitored and safety reviewed regularly.
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