I-SPY TRIAL is a study to find out which new drugs work best for different types of breast cancer. It uses special tests like MRI scans (pictures of the inside of the body using magnets) and samples of tissue and blood to see how well the treatment is working. This study tries different drugs with regular chemotherapy to see what works better for certain breast cancer types. It looks at the cancer's "biomarker signatures", which are special features of the cancer, to decide the best treatment. If a drug doesn't seem to work well, the study will stop using it. New drugs will be tested as others finish being checked.

• Participants must be adults (18+) with certain types of breast cancer and meet specific health requirements.
• They should not have had previous cancer treatments like chemotherapy or radiation for the same cancer.
• Participants must be willing to provide tissue samples and undergo procedures like MRIs.