This study is testing a new vaccine called ExPEC9V to help prevent a serious illness caused by a bacteria named Escherichia coli (E. coli). This illness, called invasive extraintestinal pathogenic E. coli disease (IED), happens when E. coli enters the blood or other parts of the body, causing a bad infection. People aged 60 and older who have had a urinary tract infection (UTI) in the past two years can join the study.

Participants will be randomly assigned to receive either the ExPEC9V vaccine or a placebo, which is a harmless substance that does not affect the body. The study will last up to 6 years and 9 months, with follow-ups for 4 years after getting the vaccine.

Key points to consider:

• The study involves a vaccination phase and a long follow-up period.
• Participants must have had a UTI in the past two years and be willing to share medical information.
• Participants should not have certain medical conditions like end-stage kidney disease or a history of certain nerve disorders.

Participants may experience side effects like serious adverse events (SAEs) or other reactions. If interested, it's important to discuss with a doctor to ensure eligibility.