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Molecular and Cellular Characterization of Cardiac Tissue in Postnatal Development

Studying heart tissue development in babies and children.

Recruiting
20 years and younger
All
Phase N/A
  • Simplified description (AI rewritten)
  • Technical description (Original)

Study Title: Molecular and Cellular Characterization of Cardiac Tissue in Postnatal Development

This study looks at pieces of human hearts taken during necessary surgeries. The team aims to understand how calcium ions, which are tiny particles, move through heart cells to help the heart beat with the right force. They explore how these actions differ between babies and adults. Researchers also examine proteins and RNA, which are like cell instructions, to see how newborn hearts work differently. A special focus is on 3D heart cell models to better understand heart growth. This study helps us learn how to make heart therapies for babies, as current knowledge mostly focuses on adults.

  • Inclusions: Patients having heart surgeries, especially for congenital issues.
  • Exclusions: Patients with previous heart surgeries or heart rhythm issues.
  • Consider: This study involves using heart tissue from surgeries; no additional procedures are required.

This research is important because it may lead to better heart treatments for infants and young adults by understanding how their heart cells work differently from adults'.

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Study details
    Congenital Heart Disease
    Tetralogy of Fallot

NCT00243776

Emory University

13 December 2024

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