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Pragmatic Evaluation of Events And Benefits of Lipid-lowering in Older Adults

Studying cholesterol-lowering effects in older adults.

Recruiting
75 years and older
All
Phase 4

The PREVENTABLE study is looking at whether a medication called atorvastatin, which lowers fat in the blood, can help older adults stay healthier. This study involves 20,000 adults who are 75 years or older, don't have heart disease or memory issues like dementia, and live in the community. Participants will either receive atorvastatin or a placebo (a pill that looks like the medicine but has no active ingredient) for up to five years. The study wants to see if atorvastatin can reduce the risk of death, dementia, and disability, as well as minor memory problems and heart issues.

  • The study will take place over up to five years, with regular check-ins by phone and possibly in-person if needed.
  • Participants will receive the study drug or placebo by mail every 90 days.
  • Eligible participants should not have heart disease, memory issues, or have taken statins recently.

If you're interested, you can talk to a study site near you or participate remotely. It's important to know if atorvastatin is safe for you, so a doctor will help decide. Participants will have their physical and mental health checked throughout the study.

Study details
    Cognitive Impairment
    Mild
    Dementia
    Cardiovascular Diseases

NCT04262206

Duke University

13 December 2024

Step 1 Get in touch with the nearest study center
What happens next?
  • You can expect the study team to contact you via email or phone in the next few days.
  • Sign up as volunteer  to help accelerate the development of new treatments and to get notified about similar trials.

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Learn more about clinical trials

What is a clinical trial?

A clinical trial is a study designed to test specific interventions or treatments' effectiveness and safety, paving the way for new, innovative healthcare solutions.

Why should I take part in a clinical trial?

Participating in a clinical trial provides early access to potentially effective treatments and directly contributes to the healthcare advancements that benefit us all.

How long does a clinical trial take place?

The duration of clinical trials varies. Some trials last weeks, some years, depending on the phase and intention of the trial.

Do I get compensated for taking part in clinical trials?

Compensation varies per trial. Some offer payment or reimbursement for time and travel, while others may not.

How safe are clinical trials?

Clinical trials follow strict ethical guidelines and protocols to safeguard participants' health. They are closely monitored and safety reviewed regularly.
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