This study is about understanding the health of people with Down syndrome after they have been treated for a type of cancer called acute leukemia. This is important because people with Down syndrome might have more health problems during cancer treatment, and we want to know if they have long-term effects too. The study will help create better health guidelines to improve their quality of life.

In the study, they will check for chronic health conditions (CHC), which are long-lasting health problems. They will also look at how the cancer treatment affects thinking and quality of life. To do this, participants might give a saliva sample, have a health check-up, and possibly give a blood sample.

• Participants must be between 6 and 40 years old, have Down syndrome, and have been treated for acute leukemia.
• All cancer treatments must have been finished at least 3 years ago.
• Participants or their guardians need to speak and read English or Spanish to fill out study forms.