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A Study Evaluating the Efficacy and Safety of Pegozafermin in Participants with MASH and Fibrosis (ENLIGHTEN-Fibrosis)

Researching Pegozafermin's effects on liver fibrosis and MASH.

Recruiting
18-75 years
All
Phase 3

This study is testing a medication called pegozafermin to see if it works and is safe for adults with a liver problem called MASH (also known as NASH) and liver scarring called fibrosis. MASH is a condition where there's fat in the liver, causing damage without alcohol use. Fibrosis means the liver is getting scarred. To join, you must be between 18 and 75 years old, have MASH confirmed by a liver test (biopsy), and have a body mass index (BMI) over 25. People with other liver diseases or severe diabetes can't join. You also can't join if your liver enzymes, called ALT or AST, are too high (over 250). The study will compare two doses of pegozafermin.

  • Study Duration: Participants need to be available for the entire study period, which includes regular visits.
  • Eligibility: You need a biopsy confirming MASH with fibrosis stage 2 or 3.
  • Risks & Benefits: There might be risks, but it could help improve liver health.
Study details
    Metabolic Dysfunction-associated Steatotic Liver Disease (MASH) / Nonalcoholic Steatohepatitis (NASH) with Fibrosis

NCT06318169

89bio, Inc.

11 January 2025

Step 1 Get in touch with the nearest study center
What happens next?
  • You can expect the study team to contact you via email or phone in the next few days.
  • Sign up as volunteer  to help accelerate the development of new treatments and to get notified about similar trials.

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