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A Study to Assess Efficacy and Safety of Adjunctive KarXT in Subjects With Inadequately Controlled Symptoms of Schizophrenia

Trial testing KarXT for schizophrenia symptoms not well managed.

Recruiting
18-65 years
All
Phase 3

This research is a Phase 3 study, meaning it's in the later stages of testing. It lasts for 6 weeks and is a randomized, double-blind, placebo-controlled trial. This means participants are randomly assigned to receive either the actual treatment or a placebo, and neither they nor the researchers know who gets which. The study focuses on people with schizophrenia who aren't fully helped by their current medication. Schizophrenia is a mental health condition that can cause hallucinations, delusions, and other thought disorders. The study tests a new treatment called KarXT (a mix of xanomeline and trospium chloride) to see if it helps more than a placebo.

Key Points to Consider:

  • The study requires outpatient visits, meaning participants don't stay overnight.
  • The study involves taking the medication twice daily.
  • Participants need to have a stable living situation and a reliable caregiver.
Study details
    Schizophrenia

NCT05145413

Karuna Therapeutics

15 March 2025

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Learn more about clinical trials

What is a clinical trial?

A clinical trial is a study designed to test specific interventions or treatments' effectiveness and safety, paving the way for new, innovative healthcare solutions.

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Participating in a clinical trial provides early access to potentially effective treatments and directly contributes to the healthcare advancements that benefit us all.

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The duration of clinical trials varies. Some trials last weeks, some years, depending on the phase and intention of the trial.

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Compensation varies per trial. Some offer payment or reimbursement for time and travel, while others may not.

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Clinical trials follow strict ethical guidelines and protocols to safeguard participants' health. They are closely monitored and safety reviewed regularly.
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