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Dose-escalation, Dose-expansion Study of Safety of Azer-cel (PBCAR0191) in Patients with R/r NHL and R/r B-cell ALL

Study testing safety of Azer-cel for certain blood cancers.

Recruiting
18 years and older
All
Phase 1

This study focuses on a new treatment called azer-cel for adults with two types of blood cancer: relapsed/refractory B-cell acute lymphoblastic leukemia (B-ALL) and non-Hodgkin lymphoma (NHL). Relapsed/refractory means the cancer has come back or hasn’t responded to previous treatments. Azer-cel is a type of therapy called CAR T-cell therapy, which uses special cells that can attack cancer cells. Before receiving azer-cel through an IV (a tube in the vein), participants will undergo lymphodepletion, a process to lower certain blood cells to make the treatment work better. Participants will be monitored for up to 15 years to ensure their safety and see how well the treatment works.

  • The study requires long-term follow-up, up to 15 years.
  • Participants must have tried at least two other cancer treatments before.
  • The study involves regular monitoring after receiving azer-cel.
Study details
    Non-Hodgkin Lymphoma
    B-cell Acute Lymphoblastic Leukemia

NCT03666000

Imugene Limited

15 March 2025

Step 1 Get in touch with the nearest study center
What happens next?
  • You can expect the study team to contact you via email or phone in the next few days.
  • Sign up as volunteer  to help accelerate the development of new treatments and to get notified about similar trials.

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Learn more about clinical trials

What is a clinical trial?

A clinical trial is a study designed to test specific interventions or treatments' effectiveness and safety, paving the way for new, innovative healthcare solutions.

Why should I take part in a clinical trial?

Participating in a clinical trial provides early access to potentially effective treatments and directly contributes to the healthcare advancements that benefit us all.

How long does a clinical trial take place?

The duration of clinical trials varies. Some trials last weeks, some years, depending on the phase and intention of the trial.

Do I get compensated for taking part in clinical trials?

Compensation varies per trial. Some offer payment or reimbursement for time and travel, while others may not.

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Clinical trials follow strict ethical guidelines and protocols to safeguard participants' health. They are closely monitored and safety reviewed regularly.
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