Germ cell tumors are a type of cancer that can occur in both children and adults, often in reproductive organs like ovaries or testicles. This study looks at how well different treatments work for these tumors. First, doctors remove the tumor, and then they watch closely to see if it comes back. This is called active surveillance. If the tumor is more serious, patients may get chemotherapy, which uses special medicines to kill cancer cells.
Key Points:
- Length of Study: Patients will be followed for up to 10 years after treatment.
- Visits Needed: Regular check-ups with scans and blood tests during and after treatment.
- Risks: Chemotherapy can have side effects like hearing loss or nerve problems.
Patients are put into groups based on their age and type of tumor. They may get one of two chemotherapy plans: one uses a drug called carboplatin, and the other uses cisplatin, both paired with other cancer-fighting drugs. The goal is to see which works better with fewer side effects. Participation is based on age, tumor type, and health conditions. Pregnant or breastfeeding women, and those not willing to use birth control during treatment, cannot join certain parts of the study.