This study looks at how well a treatment called "Microfragmented Adipose Tissue" (MFat) works compared to a simple saltwater (saline) injection for knee osteoarthritis. Osteoarthritis is a joint disease causing pain and stiffness. MFat involves using a person's own fat tissue to help heal their knee. In this study, some participants will receive the MFat injection, while others will get the saline injection, and neither the participants nor the doctors will know which one they received. This type of study is called double-blinded and randomized.

• Participants must be at least 18 years old, have knee osteoarthritis (Grade 2 or 3), and not have improved with regular treatments like physical therapy or pain medicine.
• Participants need to attend several follow-up visits and must stop using certain pain medications before and during the study.
• The study will take place at up to 20 locations across the United States, involving 173 participants.

It's important to agree to all the rules, including signing consent forms and being able to return for follow-up visits. This study may help find a new way to relieve knee pain. Always talk to your doctor to see if joining a study is right for you.