The study looks at a medicine called sirolimus to see if it can help slow down a lung disease called Lymphangioleiomyomatosis (LAM). LAM is a rare condition where abnormal cells grow in the lungs. Sirolimus is being tested at a low dose of 1 mg per day for two years to see if it can stop the disease from getting worse. To be in the study, you need to be a woman aged 18 or older with certain lung test results, and you must not have other serious health problems or be pregnant.

During the study, participants will have lung function tests every four months. You will either receive sirolimus or a placebo, which is a pill with no medicine in it. The study aims to see if sirolimus helps keep lung function stable compared to the placebo group.

• The study lasts for 2 years with lung tests every 4 months.
• Participants must be women aged 18 or older with specific lung function criteria.
• Potential side effects and medical history will be considered to ensure safety.