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Safety and Tolerability Study of INCB057643 in Participants With Myelofibrosis and Other Advanced Myeloid Neoplasms

Study on INCB057643 for patients with myelofibrosis and advanced myeloid neoplasms.

Recruiting
18 years and older
All
Phase 1

This study is about testing a new drug called INCB057643 for people with a type of blood cancer called myelofibrosis (MF) and other similar diseases. Myelofibrosis is a condition where your bone marrow, which makes blood cells, doesn't work properly. Some participants will take INCB057643 alone, and others will take it with another medicine, ruxolitinib.

To join, you need to be at least 18 years old and have tried other treatments without success. You also shouldn't have any other treatment options that might help you, according to your doctor. You need to have a life expectancy of at least 24 weeks and agree to take precautions to avoid pregnancy.

  • Study Length: Participants will be involved for a period based on the response to the treatment.
  • Treatment: Some will get INCB057643 alone, others with ruxolitinib.
  • Risks: Possible side effects and need to avoid certain medications.

If you have received another drug called a BET inhibitor before, you cannot join. Also, you must not have certain medical issues, like heart problems or active infections.

Study details
    Myelofibrosis
    Myelodysplastic Syndrome
    Myelodysplastic/Myeloproliferative Neoplasm Overlap Syndrome
    Myeloproliferative Neoplasm
    Relapsed or Refractory Primary Myelofibrosis
    Secondary Myelofibrosis (Post-Polycythemia Vera Myelofibrosis
    Post-Essential Thrombocythemia Myelofibrosis)
    ET (Essential Thrombocythemia)

NCT04279847

Incyte Corporation

15 March 2025

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Learn more about clinical trials

What is a clinical trial?

A clinical trial is a study designed to test specific interventions or treatments' effectiveness and safety, paving the way for new, innovative healthcare solutions.

Why should I take part in a clinical trial?

Participating in a clinical trial provides early access to potentially effective treatments and directly contributes to the healthcare advancements that benefit us all.

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The duration of clinical trials varies. Some trials last weeks, some years, depending on the phase and intention of the trial.

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Compensation varies per trial. Some offer payment or reimbursement for time and travel, while others may not.

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Clinical trials follow strict ethical guidelines and protocols to safeguard participants' health. They are closely monitored and safety reviewed regularly.
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