This study tests a drug called lorundrostat to see if it can help lower high blood pressure. High blood pressure, or hypertension, means the heart has to work extra hard to pump blood through the body. Lorundrostat is an aldosterone synthase inhibitor, which helps reduce blood pressure by blocking a chemical called aldosterone that makes the body hold onto salt and water. The study is for adults who already take 2 to 5 blood pressure medicines, but their blood pressure is still too high. Participants will first follow a set plan with their current medicines, and then they will be randomly given either lorundrostat or a placebo (a pill that looks like medicine but isn't). The study will take place across 75-100 sites in the U.S. and includes several visits, including an end of study visit. Some may be invited to continue the study with an open-label extension, where everyone gets lorundrostat.

• Length of Study: Includes a run-in phase, a treatment phase, and a washout period.
• Visits Needed: Multiple visits, including a final end of study visit.
• Risks: Possible side effects like changes in potassium or sodium levels.