The IRONMAN study is for men with advanced prostate cancer. Prostate cancer is a disease where cells in the prostate grow uncontrollably. This study will take place in many countries, including the US, UK, and Australia. It aims to enroll 5,000 men to understand how different treatments work and improve patient outcomes. Men with certain types of advanced prostate cancer can join. Participants will provide blood samples and answer questions about their health and treatment. The study will last at least five years, with check-ins every three months. Researchers will use the information to find the best treatment sequences and understand how different people respond to treatment. The study also looks at the safety and side effects of treatments. This research could help future patients get better care. To join, you must be 21 or older, have a confirmed prostate cancer diagnosis, and be willing to share your health information.