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ADP-A2M4CD8 Monotherapy and in Combination With Nivolumab in HLA-A2+ Subjects With MAGE-A4 Positive Ovarian Cancer (SURPASS-3)

Testing new treatment for certain ovarian cancer patients.

Recruiting
18-75 years
Female
Phase 2

This clinical trial is testing a new treatment for ovarian cancer. The trial is in phase 2, which means it is checking how well the treatment works and its safety. The treatment involves a new drug called ADP-A2M4CD8, used alone or with another drug called nivolumab. Nivolumab is a type of medicine that helps the immune system fight cancer cells.

Participants must be HLA-A2+ and have MAGE-A4 positive ovarian cancer. HLA-A2 is a specific protein on cells that helps the immune system recognize them. MAGE-A4 is a protein found in some cancer cells. Participants need to be between 18 and 75 years old and have certain health conditions to join. The study will have regular check-ups and tests to monitor the effects of the treatment.

Consider these key points:

  • The study requires commitment to regular hospital visits for treatment and check-ups.
  • Participants must not have certain other illnesses or be pregnant.
  • There might be risks, like side effects from the drugs.
Study details
    Ovarian Cancer

NCT05601752

Adaptimmune

12 October 2024

Step 1 Get in touch with the nearest study center
What happens next?
  • You can expect the study team to contact you via email or phone in the next few days.
  • Sign up as volunteer  to help accelerate the development of new treatments and to get notified about similar trials.

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Learn more about clinical trials

What is a clinical trial?

A clinical trial is a study designed to test specific interventions or treatments' effectiveness and safety, paving the way for new, innovative healthcare solutions.

Why should I take part in a clinical trial?

Participating in a clinical trial provides early access to potentially effective treatments and directly contributes to the healthcare advancements that benefit us all.

How long does a clinical trial take place?

The duration of clinical trials varies. Some trials last weeks, some years, depending on the phase and intention of the trial.

Do I get compensated for taking part in clinical trials?

Compensation varies per trial. Some offer payment or reimbursement for time and travel, while others may not.

How safe are clinical trials?

Clinical trials follow strict ethical guidelines and protocols to safeguard participants' health. They are closely monitored and safety reviewed regularly.
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