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A Study on the Safety of TAK-279 and Whether it Can Reduce Inflammation in the Bowel of Participants With Moderately to Severely Active Crohn's Disease

Researching TAK-279's safety and inflammation reduction in Crohn's disease.

Recruiting
18-75 years
All
Phase 2

Crohn's disease (CD) is a condition that causes swelling and irritation in the digestive system. This study is testing a new drug called TAK-279 to see if it can help reduce this inflammation compared to a placebo, which is a harmless pill with no medicine. The study will also check for any side effects, which are unwanted reactions to the medicine, and how well participants can handle these side effects. Doctors will use a test called an endoscopy to look inside the bowel to see if the drug is working.

Participants will take the medication for 52 weeks (1 year) and need to visit the study clinic 15 times. To join, participants must be between 18-75 years old, have a confirmed diagnosis of active Crohn's disease, and have tried other treatments without success. They cannot join if they have other bowel diseases, need surgery, or have certain medical devices like an ostomy bag.

  • The study lasts around 60 weeks in total, including extra time for checking safety.
  • Participants will be randomly given one of three doses of TAK-279 or a placebo.
  • About 268 people will join this study from different places around the world.
Study details
    Crohn's Disease

NCT06233461

Takeda

15 March 2025

Step 1 Get in touch with the nearest study center
What happens next?
  • You can expect the study team to contact you via email or phone in the next few days.
  • Sign up as volunteer  to help accelerate the development of new treatments and to get notified about similar trials.

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