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Biomarker-Driven Radiation Therapy Dose Reduction After Transoral Robotic Surgery for the Treatment of HPV-Positive Oropharyngeal Cancer

Testing reduced radiation after robotic surgery for HPV-positive throat cancer.

Recruiting
18 years and older
All
Phase 2

This study is about treating HPV-positive oropharyngeal cancer, which is a type of cancer found in the throat and mouth. HPV is a virus that can cause this cancer, but it usually has a better outcome than other throat cancers. Normally, after a special surgery called *transoral robotic surgery*, patients receive a treatment called radiation therapy. Radiation therapy uses strong rays to kill cancer cells. However, it can make swallowing hard over time. This study is trying to see if giving a lower dose of radiation after surgery can make swallowing easier and improve life quality. Patients who have no remaining cancer signs after surgery will get a reduced radiation dose for 3 weeks, while others will receive the usual treatment. After treatment, patients will have check-ups at 3, 6, 12, 18, and 24 months.

  • Study involves 3 weeks of reduced radiation therapy for eligible patients.
  • Regular follow-ups after treatment to monitor progress.
  • Participants must meet specific health criteria to join.
Study details
    Clinical Stage I HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8
    Oropharyngeal HPV-Positive Squamous Cell Carcinoma

NCT05387915

Emory University

13 December 2024

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