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Testing Drug Treatments After CAR T-cell Therapy in Patients With Relapsed/Refractory Diffuse Large B-cell Lymphoma

Testing new drug treatments after CAR T-cell therapy for lymphoma patients.

Recruiting
18 years and older
All
Phase 2

This study looks at patients with diffuse large B-cell lymphoma (a type of blood cancer) that has come back or not responded to treatment. It checks if two drugs, mosunetuzumab and polatuzumab vedotin, help after patients have had chemotherapy and a special treatment called CAR T-cell therapy. CAR T-cell therapy uses the patient's own immune cells to fight cancer. The study has four groups: one gets mosunetuzumab, another gets polatuzumab vedotin, the third gets both, and the last just gets watched. This trial aims to see if these drugs can keep cancer from growing further.

  • The trial involves several visits for treatment and monitoring.
  • Participants are randomly placed in one of four study groups.
  • There may be risks, including side effects from the drugs.
Study details
    Diffuse Large B-Cell Lymphoma
    Grade 3b Follicular Lymphoma
    Primary Mediastinal (Thymic) Large B-Cell Lymphoma
    Recurrent Diffuse Large B-Cell Lymphoma
    Refractory Diffuse Large B-Cell Lymphoma
    Transformed Follic Lymph to Diff Large B-Cell Lymphoma
    Transformed Marg Zone Lymph to Diff Large B-Cell Lymphoma

NCT05633615

SWOG Cancer Research Network

30 March 2025

Step 1 Get in touch with the nearest study center
What happens next?
  • You can expect the study team to contact you via email or phone in the next few days.
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