Babies born too early can get a lung problem called bronchopulmonary dysplasia (*BPD*), which affects their growth and development. Doctors often use medicine called diuretics, like furosemide, to help babies with early BPD. The PRIMED study wants to learn if diuretics really help babies short-term and if they should be used long-term. In this study, each baby will try furosemide and a fake pill (*placebo*) to see if it helps their breathing.

• Study will last at least 28 days in the hospital.
• Babies must be born before 28 weeks and need breathing help.
• Parents should know their baby will switch between real medicine and placebo.

This study will help doctors decide if more babies should get long-term diuretics. It's important for parents to know that their baby's response to the medicine will be closely watched, and the study is designed to find the best way to help babies with BPD. If your baby has certain medical conditions or is on certain medicines, they may not be able to join the study.