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Datopotamab Deruxtecan (Dato-DXd) and Pembrolizumab With or Without Platinum Chemotherapy in 1L Non-Small Cell Lung Cancer (TROPION-Lung07)

Testing new lung cancer treatments with Datopotamab, Pembrolizumab, and chemotherapy.

Recruiting
18 years and older
All
Phase 3
  • Simplified description (AI rewritten)
  • Technical description (Original)

This study looks at how well two cancer drugs, **datopotamab deruxtecan (Dato-DXd)** and **pembrolizumab**, work alone and with **platinum chemotherapy** for treating a type of lung cancer called **non-small cell lung cancer (NSCLC)**. It is for people who haven't had treatment for advanced or metastatic NSCLC before. **Metastatic** means the cancer has spread to other parts of the body.

The main goals are to see how long patients live without the cancer growing (called **Progression-Free Survival, PFS**) and how long they live overall (called **Overall Survival, OS**). Patients will be randomly put into one of three groups to get different treatments. The study includes a **Screening Period** to check eligibility, a **Treatment Period**, and a **Follow-up Period** to monitor health after treatment.

  • The study involves three treatments: Dato-DXd with pembrolizumab, with or without platinum; or pembrolizumab with platinum and another drug called pemetrexed.
  • Participants must be 18 or older and have specific lung cancer without certain genetic changes.
  • Some restrictions include having no previous treatments for advanced NSCLC and no serious heart or immune system issues.
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Study details
    Metastatic Non Small Cell Lung Cancer

NCT05555732

Daiichi Sankyo

8 March 2025

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