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Two Studies for Patients With Unfavorable Intermediate Risk Prostate Cancer Testing Less Intense Treatment for Patients With a Low Gene Risk Score and Testing a More Intense Treatment for Patients With a Higher Gene Risk Score

Clinical trial: Testing treatments for prostate cancer based on gene risk score.

Recruiting
18 years and older
Male
Phase 3

This study is for men with prostate cancer to see if different treatments work better based on a special test called the Decipher risk score. This test helps to figure out if the cancer might spread. If the score is low, patients will just have radiation therapy (using high-energy rays to kill cancer cells), instead of the usual radiation plus hormone therapy (which lowers male hormones that help cancer grow). If the score is high, patients will try an extra medicine called darolutamide with the usual treatment.

  • This study lasts up to 60 months with multiple follow-up visits.
  • Participants may receive radiation, hormone therapy, or darolutamide, based on their risk score.
  • Risks include possible side effects from treatments, like fatigue or hormonal changes.

To join, you must be 18 or older, have certain prostate cancer conditions, and be healthy enough for treatment. Patients can't join if they've had certain past treatments or other serious health issues. Note: This study involves several visits and assessments over time.

Study details
    Prostate Adenocarcinoma

NCT05050084

NRG Oncology

25 January 2025

Step 1 Get in touch with the nearest study center
What happens next?
  • You can expect the study team to contact you via email or phone in the next few days.
  • Sign up as volunteer  to help accelerate the development of new treatments and to get notified about similar trials.

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FAQs

Learn more about clinical trials

What is a clinical trial?

A clinical trial is a study designed to test specific interventions or treatments' effectiveness and safety, paving the way for new, innovative healthcare solutions.

Why should I take part in a clinical trial?

Participating in a clinical trial provides early access to potentially effective treatments and directly contributes to the healthcare advancements that benefit us all.

How long does a clinical trial take place?

The duration of clinical trials varies. Some trials last weeks, some years, depending on the phase and intention of the trial.

Do I get compensated for taking part in clinical trials?

Compensation varies per trial. Some offer payment or reimbursement for time and travel, while others may not.

How safe are clinical trials?

Clinical trials follow strict ethical guidelines and protocols to safeguard participants' health. They are closely monitored and safety reviewed regularly.
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