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A Phase 2/3 Study in Adult and Pediatric Participants With SCD

Study for adults and kids with Sickle Cell Disease (SCD).

Recruiting
6-65 years
All
Phase 2/3

Study Overview: This study is for people with sickle cell disease (SCD), a condition where red blood cells become sickle-shaped, making it hard for blood to flow smoothly. The study tests a medicine called osivelotor to see if it is safe and helps patients. The study has three parts:

  • Part A: Tests the safety and best dose of osivelotor in adults.
  • Part B: Compares osivelotor with a placebo (a pill with no medicine) in adults and teens for 48 weeks.
  • Part C: Looks at how osivelotor is absorbed in children's bodies and its safety.

Eligibility: To join, you must have stable hemoglobin (Hb) levels and be on a steady dose of some SCD treatments. You should not have had more than 10 vaso-occlusive crises (VOCs) in the last year. Pregnant or breastfeeding women cannot join.

Key Points:

  • Participation can last up to 48 weeks.
  • You may be required to visit the clinic multiple times.
  • There are risks, like any study, and osivelotor's effects are still being studied.

Note: This study is not suitable if you recently had certain treatments or hospitalizations.

Study details
    Sickle Cell Disease

NCT05431088

Pfizer

12 October 2024

Step 1 Get in touch with the nearest study center
What happens next?
  • You can expect the study team to contact you via email or phone in the next few days.
  • Sign up as volunteer  to help accelerate the development of new treatments and to get notified about similar trials.

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Learn more about clinical trials

What is a clinical trial?

A clinical trial is a study designed to test specific interventions or treatments' effectiveness and safety, paving the way for new, innovative healthcare solutions.

Why should I take part in a clinical trial?

Participating in a clinical trial provides early access to potentially effective treatments and directly contributes to the healthcare advancements that benefit us all.

How long does a clinical trial take place?

The duration of clinical trials varies. Some trials last weeks, some years, depending on the phase and intention of the trial.

Do I get compensated for taking part in clinical trials?

Compensation varies per trial. Some offer payment or reimbursement for time and travel, while others may not.

How safe are clinical trials?

Clinical trials follow strict ethical guidelines and protocols to safeguard participants' health. They are closely monitored and safety reviewed regularly.
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