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Pragmatic Pediatric Trial of Balanced Versus Normal Saline Fluid in Sepsis

Study comparing fluid types for treating sepsis in children.

Recruiting
2-17 years
All
Phase 3

This study aims to find out which type of fluid, **balanced fluid** like Lactated Ringer's or **normal saline**, is better for treating children with **septic shock**. Septic shock is a serious condition where the body has an overwhelming reaction to infection, which can lead to organ failure and even death. The study will compare these fluids to see which one helps the kidneys recover better and is safer overall. Many children around the world suffer from septic shock, and finding the best treatment can save lives.

**Key Points to Consider:**

  • This study will take place in over 30 locations and will monitor children for 30 days.
  • Your child may receive either fluid because we don't know which is better yet.
  • Parental permission is needed, but if it's an emergency, there might be exceptions.

For your child to join, they must be between 2 months and 18 years old, and doctors must suspect septic shock. Some children might not be eligible if they have conditions like severe liver or kidney issues. This study is important to help doctors learn the best way to help kids with septic shock.

Study details
    Shock
    Septic

NCT04102371

Children's Hospital of Philadelphia

10 October 2024

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Learn more about clinical trials

What is a clinical trial?

A clinical trial is a study designed to test specific interventions or treatments' effectiveness and safety, paving the way for new, innovative healthcare solutions.

Why should I take part in a clinical trial?

Participating in a clinical trial provides early access to potentially effective treatments and directly contributes to the healthcare advancements that benefit us all.

How long does a clinical trial take place?

The duration of clinical trials varies. Some trials last weeks, some years, depending on the phase and intention of the trial.

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Compensation varies per trial. Some offer payment or reimbursement for time and travel, while others may not.

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Clinical trials follow strict ethical guidelines and protocols to safeguard participants' health. They are closely monitored and safety reviewed regularly.
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