This study is for adults with major depressive disorder (MDD), which means they feel very sad or empty for a long time. They also have **anhedonia**, a big word meaning they don't enjoy things they used to like. The study is testing a medicine called **aticaprant**, given with an antidepressant, to see if it helps people with MDD who haven't felt better with their current medicine, which is a type of drug called **SSRI** or **SNRI**. SSRI means selective serotonin reuptake inhibitor, and SNRI means serotonin-norepinephrine reuptake inhibitor. These medicines help balance chemicals in the brain to boost mood.
Key Points:- The study lasts about 6 months, with regular visits to the doctor.
- Participants will receive either aticaprant or a placebo (a sugar pill).
- There may be some side effects, like headaches or nausea, but doctors will monitor closely.
To join, you must be stable with no serious health issues and currently taking an SSRI or SNRI for at least 6 weeks. You can't join if you've tried multiple antidepressants without success or have certain mental health diagnoses like bipolar disorder.