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Pivotal 1 Study of ABBV-RGX-314 (Also Known as RGX-314) Gene Therapy Administered Via Subretinal Delivery One Time in Participants With nAMD

Study on RGX-314 gene therapy for nAMD patients.

Recruiting
50-89 years
All
Phase 2/3

RGX-314 Gene Therapy Study is a clinical trial for people with a serious eye problem called neovascular age-related macular degeneration (wet AMD). Wet AMD causes vision loss because of new, leaky blood vessels in the eye. Current treatments require frequent eye injections to help prevent losing more sight. RGX-314 is being tested as a possible one-time treatment to make managing wet AMD easier.

This study will check how well RGX-314 works compared to another medicine, ranibizumab, by looking at changes in vision. Around 300 people will join the study, which will have three different groups. To join, you must be 50-89 years old, have a specific vision score, and have had certain eye treatments before. Conditions like other eye diseases, recent heart problems, or past gene therapy treatments could exclude you.

  • Participation involves several clinic visits over the study period.
  • This is a Phase 2b/3 study, meaning it’s advanced in testing for safety and effectiveness.
  • Participants might receive either RGX-314 or the comparison treatment.
Study details
    AMD
    nAMD
    Wet Age-related Macular Degeneration
    wAMD
    Wet AMD
    CNV
    Neovascular AMD
    Neovascular Age-related Macular Degeneration
    Choroidal Neovascularization

NCT04704921

AbbVie

1 February 2025

Step 1 Get in touch with the nearest study center
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  • You can expect the study team to contact you via email or phone in the next few days.
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Learn more about clinical trials

What is a clinical trial?

A clinical trial is a study designed to test specific interventions or treatments' effectiveness and safety, paving the way for new, innovative healthcare solutions.

Why should I take part in a clinical trial?

Participating in a clinical trial provides early access to potentially effective treatments and directly contributes to the healthcare advancements that benefit us all.

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The duration of clinical trials varies. Some trials last weeks, some years, depending on the phase and intention of the trial.

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Compensation varies per trial. Some offer payment or reimbursement for time and travel, while others may not.

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Clinical trials follow strict ethical guidelines and protocols to safeguard participants' health. They are closely monitored and safety reviewed regularly.
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