This study looks at how well a drug called Afimetoran works for people with a condition called Systemic Lupus Erythematosus, or **SLE**. SLE is a disease where the body's defense system attacks its own tissues, causing problems like joint pain and rashes. The study compares Afimetoran with a **placebo** (a fake treatment) to see if it is safe and effective. For those who first get the placebo, they will get a chance to try Afimetoran later in the study.

To join, you must have been diagnosed with SLE at least 12 weeks before the study starts. You should test positive for certain antibodies (proteins in the blood), and have a disease activity score above a certain level. You cannot join if you have severe kidney problems caused by lupus or other specific conditions.

• The study may last a long time, as it includes an extension period for more data collection.
• Participants will need to visit the study site for tests and check-ups.
• Risks or side effects of Afimetoran will be closely monitored.