The study is about a special balloon catheter coated with a drug called **Paclitaxel**. This tool is used to help people with a heart problem called **in-stent restenosis (ISR)**. ISR happens when a blood vessel that was treated before gets narrow again. The catheter helps open up blood vessels that are 2.0 mm to 4.0 mm wide and up to 36 mm long. Participants in this study will be part of a group where everyone gets the same treatment without random assignment.

• Participants must be at least 18 years old and agree to follow all study rules.
• The study will compare the new catheter to a usual treatment called balloon angioplasty.
• Women who can have babies must use birth control during and after the study for a year.

Some people can’t join, like those with serious illnesses, allergies to the drug, or recent heart surgeries. If you want to participate, you need to understand the procedures and risks, and sign a form agreeing to the study. Always talk to your doctor to see if joining is right for you.