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A Study to Investigate the Safety, Tolerability, and Pharmacokinetics of Oral GSK4172239D Compared With Placebo in Sickle Cell Disease Participants Aged 18 to 50 Years

Testing safety and effects of GSK4172239D for sickle cell patients.

Recruiting
18-50 years
All
Phase 1

This study will test a new medicine, *GSK4172239D*, for people aged 18-50 with **Sickle Cell Disease (SCD)**. SCD is a blood disorder where red blood cells shape like sickles, causing pain and other problems. This study will check if the medicine is safe and how it works in the body. There will be three parts: Screening, Treatment, and Follow-Up. Participants will take either the medicine or a *placebo* (a pill with no medicine) once. The study will last at least 20 days. Some will take the medicine again after eating a high-fat meal to see if food changes how the medicine works.

  • The study requires men to use protection or be abstinent to prevent pregnancy.
  • Participants must have a body weight over 50 kg (about 110 lbs).
  • People with serious health problems or recent medicine use may not join.

Think about the time commitment and if you meet the health criteria before joining. This study helps scientists learn more about treating SCD, but there might be risks since it's a new medicine. Always discuss with your healthcare provider before participating.

Study details
    Hematologic Diseases
    Anaemia
    Sickle Cell

NCT05660265

GlaxoSmithKline

15 March 2025

Step 1 Get in touch with the nearest study center
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  • You can expect the study team to contact you via email or phone in the next few days.
  • Sign up as volunteer  to help accelerate the development of new treatments and to get notified about similar trials.

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What is a clinical trial?

A clinical trial is a study designed to test specific interventions or treatments' effectiveness and safety, paving the way for new, innovative healthcare solutions.

Why should I take part in a clinical trial?

Participating in a clinical trial provides early access to potentially effective treatments and directly contributes to the healthcare advancements that benefit us all.

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The duration of clinical trials varies. Some trials last weeks, some years, depending on the phase and intention of the trial.

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Compensation varies per trial. Some offer payment or reimbursement for time and travel, while others may not.

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Clinical trials follow strict ethical guidelines and protocols to safeguard participants' health. They are closely monitored and safety reviewed regularly.
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