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Ramucirumab Plus Pembrolizumab vs Usual Care for Treatment of Stage IV or Recurrent Non-Small Cell Lung Cancer Following Immunotherapy, Pragmatica-Lung Study

Testing new drug combo for advanced lung cancer after immunotherapy.

Recruiting
18 years and older
All
Phase 3

This study looks at new treatment options for people with stage IV or returning non-small cell lung cancer, a type of cancer that affects the lungs. It compares the effects of using two drugs, ramucirumab and pembrolizumab, against regular chemotherapy. Ramucirumab is a kind of special medicine called a monoclonal antibody that helps stop cancer from growing by preventing new blood vessels from forming. Pembrolizumab is another monoclonal antibody that helps the immune system fight cancer. The main goal is to see if these two drugs together help patients live longer than chemotherapy alone. Patients will be split into two groups: one will get the standard chemotherapy, and the other will receive the new drug combination through an IV (a needle in a vein).

  • The study involves getting drugs either through an IV or as usual chemotherapy.
  • Participants must be 18 or older and have previously received specific treatments.
  • Those who join this study cannot partake in other experimental treatments during it.
Study details
    Recurrent Lung Non-Small Cell Carcinoma
    Stage IV Lung Cancer AJCC v8

NCT05633602

SWOG Cancer Research Network

13 December 2024

Step 1 Get in touch with the nearest study center
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  • You can expect the study team to contact you via email or phone in the next few days.
  • Sign up as volunteer  to help accelerate the development of new treatments and to get notified about similar trials.

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Learn more about clinical trials

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A clinical trial is a study designed to test specific interventions or treatments' effectiveness and safety, paving the way for new, innovative healthcare solutions.

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Participating in a clinical trial provides early access to potentially effective treatments and directly contributes to the healthcare advancements that benefit us all.

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Clinical trials follow strict ethical guidelines and protocols to safeguard participants' health. They are closely monitored and safety reviewed regularly.
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