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Study of Radiation Therapy Followed by Atezolizumab in Stage II or III Non-small Cell Lung Cancer Patients

Exploring radiation and Atezolizumab for certain lung cancer stages.

Recruiting
18 years and older
All
Phase 2

This study checks if combining radiation therapy and atezolizumab helps people with stage II or III non-small cell lung cancer (NSCLC). Radiation therapy uses strong rays to kill cancer cells. Atezolizumab is a monoclonal antibody, a type of treatment that helps the immune system fight cancer. This study wants to see how safe these treatments are together and if they help patients.

  • The study lasts up to 12 months, with treatment cycles every 21 days.
  • Participants will undergo CT or MRI scans and give blood samples during the study.
  • Follow-up visits occur at 6 weeks, then every 12 months for 1 year, and every 6 months up to 3 years.

Participants must have NSCLC and meet specific health criteria. They should not be able to have surgery or chemoradiation. They must have measurable disease through CT or MRI scans and fit certain health standards, like having good blood counts and organ function. People with certain health conditions or who are pregnant cannot join. Participants must use effective contraception during and after the study. The study also checks for infections like hepatitis or HIV before joining.

Study details
    Lung Non-Small Cell Carcinoma
    Stage II Lung Cancer AJCC v8
    Stage III Lung Cancer AJCC v8

NCT04310020

National Cancer Institute (NCI)

30 March 2025

Step 1 Get in touch with the nearest study center
What happens next?
  • You can expect the study team to contact you via email or phone in the next few days.
  • Sign up as volunteer  to help accelerate the development of new treatments and to get notified about similar trials.

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Learn more about clinical trials

What is a clinical trial?

A clinical trial is a study designed to test specific interventions or treatments' effectiveness and safety, paving the way for new, innovative healthcare solutions.

Why should I take part in a clinical trial?

Participating in a clinical trial provides early access to potentially effective treatments and directly contributes to the healthcare advancements that benefit us all.

How long does a clinical trial take place?

The duration of clinical trials varies. Some trials last weeks, some years, depending on the phase and intention of the trial.

Do I get compensated for taking part in clinical trials?

Compensation varies per trial. Some offer payment or reimbursement for time and travel, while others may not.

How safe are clinical trials?

Clinical trials follow strict ethical guidelines and protocols to safeguard participants' health. They are closely monitored and safety reviewed regularly.
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