This study is exploring the effects of a medication called naltrexone hydrochloride ER and bupropion hydrochloride ER, known as Contrave® or Mysimba®, on heart health. The main goal is to see if taking this medicine increases the risk of major heart problems, known as major adverse cardiovascular events (MACE), compared to a placebo (a pill that has no active medicine). Participants will also get advice to eat healthier and exercise more.

To join, you need to be 18 or older, understand and agree to the study, and be overweight (BMI of 30 or more) or have specific health risks like high blood pressure or type 2 diabetes. Some people can't participate, like those with recent heart attacks, certain health conditions, or those who are pregnant.

• The study uses a placebo for comparison, so some people won't get the active medicine.
• Participants will need to follow a healthier lifestyle, including diet and exercise.
• It's important to use a smartphone app daily for the study.

If you meet the criteria and are interested, discuss it with your doctor to learn more about the risks and benefits.