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Effect of Naltrexone Hydrochloride ER and Bupropion Hydrochloride ER Combination (Contrave®/Mysimba®) on Major Adverse Cardiovascular Events (MACE)

Exploring Contrave®/Mysimba® for heart health safety in clinical trials.

Recruiting
18 years and older
All
Phase 4

This study is exploring the effects of a medication called naltrexone hydrochloride ER and bupropion hydrochloride ER, known as Contrave® or Mysimba®, on heart health. The main goal is to see if taking this medicine increases the risk of major heart problems, known as major adverse cardiovascular events (MACE), compared to a placebo (a pill that has no active medicine). Participants will also get advice to eat healthier and exercise more.

To join, you need to be 18 or older, understand and agree to the study, and be overweight (BMI of 30 or more) or have specific health risks like high blood pressure or type 2 diabetes. Some people can't participate, like those with recent heart attacks, certain health conditions, or those who are pregnant.

  • The study uses a placebo for comparison, so some people won't get the active medicine.
  • Participants will need to follow a healthier lifestyle, including diet and exercise.
  • It's important to use a smartphone app daily for the study.

If you meet the criteria and are interested, discuss it with your doctor to learn more about the risks and benefits.

Study details
    Obesity

NCT06098079

Currax Pharmaceuticals

15 February 2025

Step 1 Get in touch with the nearest study center
What happens next?
  • You can expect the study team to contact you via email or phone in the next few days.
  • Sign up as volunteer  to help accelerate the development of new treatments and to get notified about similar trials.

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FAQs

Learn more about clinical trials

What is a clinical trial?

A clinical trial is a study designed to test specific interventions or treatments' effectiveness and safety, paving the way for new, innovative healthcare solutions.

Why should I take part in a clinical trial?

Participating in a clinical trial provides early access to potentially effective treatments and directly contributes to the healthcare advancements that benefit us all.

How long does a clinical trial take place?

The duration of clinical trials varies. Some trials last weeks, some years, depending on the phase and intention of the trial.

Do I get compensated for taking part in clinical trials?

Compensation varies per trial. Some offer payment or reimbursement for time and travel, while others may not.

How safe are clinical trials?

Clinical trials follow strict ethical guidelines and protocols to safeguard participants' health. They are closely monitored and safety reviewed regularly.
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