In this study, researchers are testing a new treatment called **SELUTION SLR™ 018 DEB** for people with blockages in certain leg arteries. They want to see if it’s better than the current method, which uses a plain balloon to open arteries. This study is for people with **Peripheral Arterial Disease (PAD)**, a condition where blood flow is reduced in the arteries, specifically in the **superficial femoral artery (SFA)** and **proximal popliteal artery (PPA)**. The study will include 300 people who will be split into two groups: one group will receive the new treatment, and the other will get the regular treatment. A smaller group of 20 people will participate in a side study to understand how the drug acts in the body. **Key Points**: - **Participation**: Up to 300 subjects, with a special sub-study for 20 subjects. - **Locations**: Conducted at up to 60 sites in the US, Europe, and Asia. - **Involvement**: Regular follow-ups and evaluations are required. This study is important for those with PAD, looking for potentially better treatments. Participants need to follow specific guidelines and consent to the procedures.