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Studying Solriamfetol Modulation of TAAR-1, Dopamine, and Norepinephrine in Shift Work Disorder (SUSTAIN)

Exploring Solriamfetol for shift work disorder effects on brain chemicals.

Recruiting
18-65 years
All
Phase 3

This study is about a medicine called solriamfetol, which helps people who feel very sleepy because of working night shifts. Night shift work can mess up your sleep, and this study aims to check if solriamfetol can help. It's a Phase 3 trial, which means it's in the later stages of testing. Participants will be given either the medicine or a placebo (a pill that doesn't contain medicine) to see if solriamfetol is safe and works well. The study lasts for 12 weeks, and you will take the pill once every night shift. To join, you must be between 18 and 65 years old and meet specific sleep disorder criteria. You cannot join if you've used solriamfetol before or can't follow the study rules. If you choose to participate, you'll help researchers learn more about treating shift work sleepiness.

  • Study lasts 12 weeks, with medicine taken nightly.
  • Randomly assigned to solriamfetol or placebo group.
  • Must be aged 18-65 and meet sleep disorder criteria.
Study details
    Excessive Sleepiness
    Shift-work Disorder

NCT06568367

Axsome Therapeutics, Inc.

25 January 2025

Step 1 Get in touch with the nearest study center
What happens next?
  • You can expect the study team to contact you via email or phone in the next few days.
  • Sign up as volunteer  to help accelerate the development of new treatments and to get notified about similar trials.

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Learn more about clinical trials

What is a clinical trial?

A clinical trial is a study designed to test specific interventions or treatments' effectiveness and safety, paving the way for new, innovative healthcare solutions.

Why should I take part in a clinical trial?

Participating in a clinical trial provides early access to potentially effective treatments and directly contributes to the healthcare advancements that benefit us all.

How long does a clinical trial take place?

The duration of clinical trials varies. Some trials last weeks, some years, depending on the phase and intention of the trial.

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Compensation varies per trial. Some offer payment or reimbursement for time and travel, while others may not.

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Clinical trials follow strict ethical guidelines and protocols to safeguard participants' health. They are closely monitored and safety reviewed regularly.
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