Image

De-Escalation of Breast Radiation Trial for Hormone Sensitive, HER-2 Negative, Oncotype Recurrence Score Less Than or Equal to 18 Breast Cancer (DEBRA)

Participate in a trial for specific low-risk breast cancer treatment.

Recruiting
50-70 years
All
Phase 3

DEBRA Study is a Phase III trial to see if surgery and hormone treatment alone work as well as adding radiation after breast-conserving surgery for certain breast cancer patients. Breast-conserving therapy often includes radiation to prevent cancer from coming back. But, radiation can be burdensome. This study will see if it can be safely skipped for patients with hormone-sensitive and HER2-negative breast cancer that have low risk of recurrence. HER2-negative means the cancer cells do not have a protein called HER2 on their surface, and hormone-sensitive means the cancer grows in response to hormones like estrogen or progesterone.

  • This study is for patients who have completed surgery, not started hormone therapy, and have a recurrence score of 18 or less.
  • The study needs patients to agree to hormone therapy for at least 5 years.
  • It's important to have no signs of cancer spreading elsewhere in the body before joining.
Study details
    Stage I Breast Cancer

NCT04852887

NRG Oncology

8 March 2025

Step 1 Get in touch with the nearest study center
What happens next?
  • You can expect the study team to contact you via email or phone in the next few days.
  • Sign up as volunteer  to help accelerate the development of new treatments and to get notified about similar trials.

You are contacting

Investigator Avatar

Primary Contact

site

  Other languages supported:

FAQs

Learn more about clinical trials

What is a clinical trial?

A clinical trial is a study designed to test specific interventions or treatments' effectiveness and safety, paving the way for new, innovative healthcare solutions.

Why should I take part in a clinical trial?

Participating in a clinical trial provides early access to potentially effective treatments and directly contributes to the healthcare advancements that benefit us all.

How long does a clinical trial take place?

The duration of clinical trials varies. Some trials last weeks, some years, depending on the phase and intention of the trial.

Do I get compensated for taking part in clinical trials?

Compensation varies per trial. Some offer payment or reimbursement for time and travel, while others may not.

How safe are clinical trials?

Clinical trials follow strict ethical guidelines and protocols to safeguard participants' health. They are closely monitored and safety reviewed regularly.
Add a private note
  • abc Select a piece of text.
  • Add notes visible only to you.
  • Send it to people through a passcode protected link.