Study Summary: This study focuses on testing NOE-115, a new medicine, to see if it's safe and effective for treating hot flashes, a common symptom during menopause. Menopause is when a woman's periods stop, usually around the ages of 45-60. Hot flashes are sudden feelings of warmth, often with sweating. NOE-115 is a monoamine modulator, which means it helps balance chemicals in the brain.

Study Details: The study lasts about 12 weeks. There are three parts: a 4-week screening (checking if you can join), a 4-week treatment (taking the medicine daily), and a 4-week follow-up (checking how you're doing after treatment). There are two groups: the first group takes a set dose, and if it's safe, the second group might have their dose increased based on safety checks.

• Participation: Women aged 45-60 with frequent hot flashes can join.
• Time Commitment: Study lasts about 12 weeks with clinic visits for check-ups.
• Safety Checks: Regular visits ensure the medicine's safety and may adjust doses.

Participants must be generally healthy, without serious health issues like heart or mental health problems. Compensation details are not mentioned.