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Efficacy and Safety of Remibrutinib Compared to Teriflunomide in Participants With Relapsing Multiple Sclerosis (RMS)

Study compares Remibrutinib and Teriflunomide for relapsing multiple sclerosis.

Recruiting
18-55 years
All
Phase 3

This study is testing two medicines, remibrutinib and teriflunomide, to see which works better and is safer for people with relapsing multiple sclerosis (RMS). RMS is a condition where the immune system mistakenly attacks the brain and spinal cord, leading to various symptoms. The study lasts up to 30 months, with a possibility to continue for another 5 years if eligible. The first part is "double-blind", meaning neither the participants nor the researchers know who gets which medicine. After this, eligible participants may continue with remibrutinib openly for 5 more years.

  • Duration: Up to 30 months initially, with a 5-year extension.
  • Eligibility: Ages 18-55 with RMS; must meet certain health criteria.
  • Risks: Potential side effects and health risks must be considered.

Participants must be between 18 to 55 years old and meet specific health criteria. They should not have certain other health issues like primary progressive multiple sclerosis or significant diseases. Before joining, discuss any personal health concerns with your doctor.

Study details
    Relapsing Multiple Sclerosis

NCT05147220

Novartis Pharmaceuticals

8 March 2025

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Learn more about clinical trials

What is a clinical trial?

A clinical trial is a study designed to test specific interventions or treatments' effectiveness and safety, paving the way for new, innovative healthcare solutions.

Why should I take part in a clinical trial?

Participating in a clinical trial provides early access to potentially effective treatments and directly contributes to the healthcare advancements that benefit us all.

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The duration of clinical trials varies. Some trials last weeks, some years, depending on the phase and intention of the trial.

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Compensation varies per trial. Some offer payment or reimbursement for time and travel, while others may not.

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Clinical trials follow strict ethical guidelines and protocols to safeguard participants' health. They are closely monitored and safety reviewed regularly.
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