Systemic Lupus Erythematosus (SLE) is a disease where the body's immune system attacks its own tissues. This study is collecting data and samples from people with SLE to help future research. Over 3,500 people from the US and Canada will join. They will be put into one of four groups based on their condition: New Onset (newly diagnosed), Active Lupus Nephritis (LN) (a type of kidney inflammation), Extra-Renal Lupus Flare (recent flare-ups outside the kidneys), or Prevalent Cases (other lupus cases).
The study will collect information like medical history and environmental factors. Participants will give samples of blood, urine, saliva, stool, and tissue. These samples will be used to study genetics, proteins, and more. The study will last up to 5 years.
- Participants must be 18 or older and able to consent.
- Pregnant individuals are not eligible.
- Participants must meet visit requirements.