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A Global Study to Assess the Effects of Durvalumab + Domvanalimab Following Concurrent Chemoradiation in Participants With Stage III Unresectable NSCLC

Studying Durvalumab + Domvanalimab effects in stage III lung cancer patients.

Recruiting
18 years and older
All
Phase 3

This study looks at a new treatment for adults with a type of lung cancer called NSCLC, which stands for Non-Small Cell Lung Cancer. The cancer must be at stage III, meaning it has grown but cannot be removed with surgery. Participants will either receive a new combination of two medicines, durvalumab and domvanalimab, or durvalumab with a fake medicine (placebo). Durvalumab is an immune therapy that helps the body fight cancer, and domvanalimab is being studied to see if it helps durvalumab work better. The study is double-blind, meaning neither the patients nor the doctors know who is getting the real medicine or the placebo. Eligible participants must be 18 or older, have received certain previous treatments, and not have other serious health issues. The study will check if the new treatment is safe and effective.

  • The study will be conducted worldwide and involve multiple centers.
  • Participants will be randomly assigned to different treatment groups.
  • Interested participants should consider potential risks and the need for regular monitoring.
Study details
    Non-Small Cell Lung Cancer

NCT05211895

AstraZeneca

22 February 2025

Step 1 Get in touch with the nearest study center
What happens next?
  • You can expect the study team to contact you via email or phone in the next few days.
  • Sign up as volunteer  to help accelerate the development of new treatments and to get notified about similar trials.

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Learn more about clinical trials

What is a clinical trial?

A clinical trial is a study designed to test specific interventions or treatments' effectiveness and safety, paving the way for new, innovative healthcare solutions.

Why should I take part in a clinical trial?

Participating in a clinical trial provides early access to potentially effective treatments and directly contributes to the healthcare advancements that benefit us all.

How long does a clinical trial take place?

The duration of clinical trials varies. Some trials last weeks, some years, depending on the phase and intention of the trial.

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Compensation varies per trial. Some offer payment or reimbursement for time and travel, while others may not.

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Clinical trials follow strict ethical guidelines and protocols to safeguard participants' health. They are closely monitored and safety reviewed regularly.
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