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Testing the Addition of the Drug Relugolix to the Usual Radiation Therapy for Advanced-Stage Prostate Cancer, The NRG Promethean Study

Trying Relugolix with radiation for advanced prostate cancer.

Recruiting
18 years and older
Male
Phase 2

This study examines if the drug Relugolix, when combined with radiation therapy, can help shrink tumors in prostate cancer patients, particularly when the cancer has spread to a limited number of other body parts (1 to 5). Prostate cancer growth is often fueled by a hormone called testosterone. Relugolix helps by lowering testosterone levels in the body, potentially slowing tumor growth. There are two groups in the study: one gets a placebo (inactive pill) and the other gets Relugolix, both with radiation therapy.

  • Participants take pills daily for 180 days and may receive radiation for 1-3 weeks.
  • The study requires several follow-up visits over 4 years after treatment ends.
  • Participants must meet specific health criteria and agree to use effective birth control during the study.
Study details
    Oligometastatic Prostate Carcinoma
    Prostate Adenocarcinoma
    Prostate Ductal Adenocarcinoma
    Prostate Intraductal Carcinoma
    Stage IVB Prostate Cancer AJCC v8

NCT05053152

NRG Oncology

15 March 2025

Step 1 Get in touch with the nearest study center
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