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A Study to Evaluate Efficacy and Safety of Intravenous Sabirnetug in Participants with Early Alzheimer's Disease (ALTITUDE-AD)

Evaluating a new Alzheimer's treatment for safety and effectiveness.

Recruiting
50-90 years
All
Phase 2

This study checks how well a medicine called *sabirnetug* works for early Alzheimer's disease. Alzheimer's makes it hard to remember things and do daily activities. In this study, some people will get sabirnetug through an IV (a tube that puts medicine directly into a vein) every four weeks. Others will get a placebo, which looks like the medicine but isn’t. The study will see if sabirnetug helps slow down the symptoms of Alzheimer’s.

**Who can join?** You need to weigh between 66 to 352 pounds. You also need to know your APOE4 genotype, which is a gene related to Alzheimer's. You should be in the early stages of Alzheimer's or have mild memory problems. A study partner, someone who knows you well, needs to help you during the study.

**Who cannot join?** If you have problems like claustrophobia, metal implants, or a pacemaker that doesn’t work with MRI, you cannot join. People with other serious brain diseases or recent cancer can’t join either. If you have severe depression or have tried to harm yourself, you won't be able to participate.

  • The study lasts several months with visits every four weeks.
  • You may receive either the study drug or a placebo.
  • Having a reliable study partner is necessary.
Study details
    Alzheimer Disease

NCT06335173

Acumen Pharmaceuticals

16 November 2024

Step 1 Get in touch with the nearest study center
What happens next?
  • You can expect the study team to contact you via email or phone in the next few days.
  • Sign up as volunteer  to help accelerate the development of new treatments and to get notified about similar trials.

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FAQs

Learn more about clinical trials

What is a clinical trial?

A clinical trial is a study designed to test specific interventions or treatments' effectiveness and safety, paving the way for new, innovative healthcare solutions.

Why should I take part in a clinical trial?

Participating in a clinical trial provides early access to potentially effective treatments and directly contributes to the healthcare advancements that benefit us all.

How long does a clinical trial take place?

The duration of clinical trials varies. Some trials last weeks, some years, depending on the phase and intention of the trial.

Do I get compensated for taking part in clinical trials?

Compensation varies per trial. Some offer payment or reimbursement for time and travel, while others may not.

How safe are clinical trials?

Clinical trials follow strict ethical guidelines and protocols to safeguard participants' health. They are closely monitored and safety reviewed regularly.
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