This study checks how well a medicine called *sabirnetug* works for early Alzheimer's disease. Alzheimer's makes it hard to remember things and do daily activities. In this study, some people will get sabirnetug through an IV (a tube that puts medicine directly into a vein) every four weeks. Others will get a placebo, which looks like the medicine but isn’t. The study will see if sabirnetug helps slow down the symptoms of Alzheimer’s.

**Who can join?** You need to weigh between 66 to 352 pounds. You also need to know your APOE4 genotype, which is a gene related to Alzheimer's. You should be in the early stages of Alzheimer's or have mild memory problems. A study partner, someone who knows you well, needs to help you during the study.

**Who cannot join?** If you have problems like claustrophobia, metal implants, or a pacemaker that doesn’t work with MRI, you cannot join. People with other serious brain diseases or recent cancer can’t join either. If you have severe depression or have tried to harm yourself, you won't be able to participate.

• The study lasts several months with visits every four weeks.
• You may receive either the study drug or a placebo.
• Having a reliable study partner is necessary.