This study looks at **Chronic Granulomatous Disease (CGD)**, a condition where certain immune cells don't work properly, making it hard to fight infections. Researchers will study **antibodies** (proteins that help fight germs) and **cytokines** (proteins that cause inflammation) in people with CGD. Blood samples will be taken from both adults and children. To be part of this study, participants must be male and diagnosed with CGD, with less than 1% activity of a protein called NADPH oxidase. This means their immune system isn't making enough of this protein to work well. Participants who have had specific treatments like a bone marrow transplant or gene therapy cannot join. Also, participants must be able to follow the instructions for giving a blood sample.

• This is an observational study, meaning no treatment will be given.
• Participants need to provide a blood sample as part of the study.
• There are specific eligibility requirements to join the study.