This study is about treating a lung condition called **Pulmonary Embolism (PE)**. PE happens when a blood clot blocks blood flow in the lungs. There are two groups in this study. One group will get a treatment called **Catheter-Directed Therapy (CDT)** along with blood thinners, and the other group will just get blood thinners. **Catheter-Directed Therapy** is a way to remove the clot using a thin tube called a catheter. The study will involve 500 people with a specific type of PE.

Eligibility: To join, you must have a confirmed PE with certain heart changes seen on a CT scan. You cannot join if you have low blood pressure, had symptoms for more than 14 days, certain blood issues, or if you are pregnant, among other criteria.

• **Duration**: This study will take some time as it involves recovery and follow-up.
• **Compensation**: Participants may receive compensation for their time and travel.
• **Risks**: There are risks involved with the treatment and procedures. Make sure to discuss with your doctor.