Study Overview: This study tests lorundrostat, which may help people with high blood pressure (hypertension) that isn't controlled by their current medication. Lorundrostat is an aldosterone synthase inhibitor (a drug that works by blocking a hormone that can raise blood pressure). Participants will be people taking 2 to 5 blood pressure medicines, one being a type of diuretic (a drug that helps your body get rid of extra salt and water).

Study Design: The study lasts for about 16 weeks. It starts with a 4-week initial period, then a 12-week phase where participants either receive the drug or a placebo (a harmless pill used for comparison). After this, those who wish can continue taking lorundrostat in an open-label study, which means they and their doctors will know they are taking the active drug.

Eligibility: Adults with specific blood pressure levels who have had hypertension for at least 6 months. Participants should not be pregnant, have certain kidney or heart conditions, or have used other experimental treatments recently.

• Participation lasts about 16 weeks initially.
• Opportunity to continue treatment in an open-label study.
• Must already be on 2 to 5 blood pressure medications.