Aortix is a device to help patients with acute decompensated heart failure (ADHF), a condition where the heart can't pump blood well, causing fluid buildup. The study compares this device to regular medicine for patients who don't respond to diuretics, drugs that help remove excess water from the body. Participants will be randomly assigned to receive either the device or standard treatment. Some patients will be in a special group to first improve their kidney function before getting more treatments. The study plans to include 268 people, aged 21 or older, at 45 medical sites in the U.S. If you have ADHF and are resistant to diuretics, you may be eligible.

• The study lasts for about 30 days with regular follow-ups.
• Participants will randomly receive either the Aortix device or standard care.
• Participants need to be in the hospital with ADHF diagnosis to join.