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Testing Radiation and HER2-targeted Therapy Versus HER2-targeted Therapy Alone for Low-risk HER2-positive Breast Cancer

Comparing treatments for low-risk HER2-positive breast cancer. Join our study!

Recruiting
40 years and older
All
Phase 3

This study focuses on patients with HER2-positive breast cancer, a type of cancer with a specific protein (HER2) that promotes cancer growth. The trial compares two treatments: one group receives only HER2-targeted therapy, while the other group receives both HER2-targeted therapy and radiotherapy (using radiation to kill cancer cells). This is a Phase III study, meaning it aims to confirm the effectiveness of treatments. The study includes patients who have had breast-conserving surgery and are at early-stage, low-risk. The aim is to see if skipping radiotherapy is safe and effective for these patients. The study is important because it could help reduce the side effects and costs linked to radiotherapy if it turns out not to be necessary for some patients.

  • Study Duration: Participants will be followed for several years.
  • Eligibility: Adults aged 40 or older with HER2-positive breast cancer who have had surgery and specific treatments.
  • Considerations: Potential risks include cancer recurrence; benefits include avoiding radiotherapy side effects.
Study details
    HER2-positive Breast Cancer

NCT05705401

NRG Oncology

8 March 2025

Step 1 Get in touch with the nearest study center
What happens next?
  • You can expect the study team to contact you via email or phone in the next few days.
  • Sign up as volunteer  to help accelerate the development of new treatments and to get notified about similar trials.

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Learn more about clinical trials

What is a clinical trial?

A clinical trial is a study designed to test specific interventions or treatments' effectiveness and safety, paving the way for new, innovative healthcare solutions.

Why should I take part in a clinical trial?

Participating in a clinical trial provides early access to potentially effective treatments and directly contributes to the healthcare advancements that benefit us all.

How long does a clinical trial take place?

The duration of clinical trials varies. Some trials last weeks, some years, depending on the phase and intention of the trial.

Do I get compensated for taking part in clinical trials?

Compensation varies per trial. Some offer payment or reimbursement for time and travel, while others may not.

How safe are clinical trials?

Clinical trials follow strict ethical guidelines and protocols to safeguard participants' health. They are closely monitored and safety reviewed regularly.
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