This study is testing a medicine called TAK-279 to see if it can reduce swelling and pain in the bowel for people with ulcerative colitis (UC). UC is when the large intestine, or bowel, gets swollen and sore. The study compares TAK-279 with a placebo, which looks like medicine but doesn't have an active ingredient.

Participants will take either TAK-279 or placebo capsules for 3 months. After that, everyone will get TAK-279 for about 1 year. The study lasts about 60 weeks total, including time for checking safety.

To join, you must be 18 to 75 years old and have moderately to severely active UC. You should have tried other treatments that didn’t work or caused problems. You cannot join if you have other bowel diseases or certain complications.

• Study duration: approximately 60 weeks, including 12 weeks on placebo or TAK-279, then 40 more weeks with TAK-279.
• Multiple visits to the clinic are required.
• The study aims to check how TAK-279 helps with symptoms and any side effects.